February 2007 Web Blast

HRC Leads Research with the Oregon Women's Study

What, exactly, is this study?

This study, to be conducted in Klamath Falls, is the first phase of a large study that will bring new understanding about a mother’s diet on her baby’s growth. We know that during early development, from conception to two years of age, humans are permanently molded by their environment. Lack of stimulation, poor feeding, and recurrent minor illnesses have immediate and delayed consequences.

Why is this study important?

The diets of women in the US have not been well studied. Even a diet of normal calories may not be properly balanced, an imbalance which may lead to long term risks for disease. By focusing on fetal nutrition, we will be able to predict long term disease outcomes. The long-term consequences of poor maternal nutrition include poor educational achievement, high rates of heart disease (coronary artery disease), stroke, and adult onset diabetes.

Why is the study being done in Klamath Falls?

The study is being carried out in Klamath Falls because it is a rural city with a stable population with about 25% of the population below poverty level. Klamath Falls family physicians are part of the Oregon Rural Practice-based Research Network (ORPRN) that coordinates studies on Oregon’s citizens to better understand ways to improve their health.

Who are the women being selected?

Three groups of 50 women are being recruited for the study.

• Group 1- Women ages 18-34 recruited using voter registration and through ads in the local newspaper.
• Group 2- Women in their first trimester of pregnancy who are being seen at Cascades East or Klamath Medical Clinic and plan to deliver at Merle West Medical Center.
• Group 3- Women in their third trimester of pregnancy being seen at these clinics.

The growth of the baby and the placenta will be measured during pregnancy in Groups 2 and 3.

Who is doing this study?

This study is being conducted by the OHSU Heart Research Center in cooperation with Oregon Rural Practice-based Research Network (ORPRN). Dr. Cynthia Morris is the Principal Investigator. Other investigators include Drs. David Barker, Kent Thornburg, Sally Segel, and Rob Ross.

How will the results affect women?

The women of Klamath Falls have the opportunity to impact the health of future generations worldwide. By identifying nutritional habits that promote healthy growth of a baby before birth and habits that slow a baby’s growth, the study will be able to specify an optimal diet, one which will lead to the improved health of future generations throughout their lives.